Hypercholesterolemia Among Children
نویسندگان
چکیده
منابع مشابه
Hypercholesterolemia in children.
During the last decade, major changes have occurred in the approach to the diagnosis and treatment of hypercholesterolemia in children. In 1993 the National Cholesterol Education Program Expert Panel on Blood Cholesterol in Children and Adolescents recommended that selective screening for the diagnosis of hypercholesterolemia be implemented, and that diagnosed children be treated based on their...
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BACKGROUND Familial hypercholesterolemia is one of the most common inherited metabolic diseases and is an autosomal dominant disorder meaning heterozygotes, or carriers, are affected. Those who are homozygous have severe disease. The average worldwide prevalence of heterozygous familial hypercholesterolemia is at least 1 in 500, although recent genetic epidemiological data from Denmark and next...
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Background—We previously demonstrated in a randomized placebo-controlled trial that 2-year pravastatin treatment induced a significant regression of carotid intima-media thickness (IMT) in 8to 18-year-old children with familial hypercholesterolemia. Subsequently, we continued to follow up these children to explore the relation between the age of statin initiation and carotid IMT after follow-up...
متن کاملGarlic extract therapy in children with hypercholesterolemia.
OBJECTIVE To determine whether garlic extract therapy is efficacious and safe in children with hypercholesterolemia. DESIGN Randomized, double-blind, placebo-controlled clinical trial. SETTING Specialized pediatric lipid disorders ambulatory clinic. PARTICIPANTS Thirty pediatric patients, aged 8 to 18 years, who had familial hyperlipidemia and a minimum fasting total cholesterol level gre...
متن کاملApolipoprotein E/intrauterine undernutrition interaction and hypercholesterolemia in children.
The inconsistency of data regarding intrauterine programming of cardiovascular risk factors may be largely caused by genetic predisposition and later lifestyle. We analyzed whether low birth weight and apolipoprotein E (Apo E) polymorphism participate in the onset of hypercholesterolemia in children. Our approach was based on hypothesis that genetically enhanced susceptibility of different indi...
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ژورنال
عنوان ژورنال: Circulation
سال: 2009
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.108.837666